钴催化的环丙烯不对称氢烷基化反应

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何斌^a, 钮大文^a^,^b^,^*()

Bin He^a, Dawen Niu^a^,^b^,^*()

a West China Hospital, Sichuan University, Chengdu 610041
b School of Chemical Engineering, Sichuan University, Chengdu 610041

文章分享

何斌, 钮大文. 钴催化的环丙烯不对称氢烷基化反应[J]. 有机化学, 2021, 41(3): 1261-1263.

Bin He, Dawen Niu. Cobalt-Catalyzed Asymmetric Hydroalkylation of Cyclopropenes[J]. Chinese Journal of Organic Chemistry, 2021, 41(3): 1261-1263.

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图式1. 含环丙烷结构的生物活性分子

Scheme 1. Bioactive molecules containing cyclopropane

图式2. 钴催化的环丙烯不对称氢烷基化

Scheme 2. Cobalt-catalyzed asymmetric hydroalkylation of cyclopropenes

图3. 立体选择性环丙醇与氧杂桥环烯烃加成反应

Scheme 3. Enantioselective and chemodivergent addition of cyclopropanols to oxabicyclic alkenes

图4. 代表性底物实例

Scheme 4. Representative examples of substrate

图5. 可能的催化循环

Scheme 5. Possible catalytic cycle

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