Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (05): 805-814.DOI: 10.6023/cjoc1201124 Previous Articles     Next Articles

Reviews

环糊精超分子组装体与核酸的相互作用

陈湧, 刘育   

  1. 南开大学化学系, 元素有机化学国家重点实验室, 天津 300071
  • 收稿日期:2012-01-12 修回日期:2012-03-07 出版日期:2012-05-25 发布日期:2012-03-23
  • 通讯作者: 刘育 E-mail:yuliu@nankai.edu.cn
  • 基金资助:

    973 重大研究计划(2011CB932500)和国家自然科学基金(20932004, 91027007)资助项目.

Supramolecular Assembly of Cyclodextrins and Its Interactions with Nucleic Acid

CHEN Yong, LIU Yu   

  1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:2012-01-12 Revised:2012-03-07 Online:2012-05-25 Published:2012-03-23
  • Supported by:

    Project supported by the 973 Program (No. 2011CB932500) and the National Natural Science Foundation of China (Nos. 20932004, 91027007).

Cyclodextrins (CDs) are a class of cyclic oligosaccharides with six to eight D-glucose units and widely applied in many fields of chemistry and biology. This reviews deals with the representative contributions in the construction of some bioactive cyclodextrin-based supramolecular assemblies, including cyclodextrin polypseudorotaxane, cyclodextrin/gold nanoparticle assembly, cyclodextrin/fullerene assembly, cyclodextrin/carbon nanotube assembly, and their interactions with nucleic acids, including the nucleic acid cleavage, condensation, delivery and the inhibition of nucleic acid enzymes.

Key words: cyclodextrin, nucleic acid, supramolecular assembly