Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2239-2247.DOI: 10.6023/cjoc201205035 Previous Articles     Next Articles

Reviews

非对称杂化的手性膦-亚磷酰胺酯配体在不对称催化反应中的应用进展

侯传金a,b, 刘小宁a, 夏英a, 胡向平b   

  1. a 大连工业大学轻工与化学工程学院 大连 116034;
    b 中国科学院大连化学物理研究所 大连 116023
  • 收稿日期:2012-05-30 修回日期:2012-07-17 出版日期:2012-12-25 发布日期:2012-07-18
  • 通讯作者: 侯传金, 胡向平 E-mail:houcj@dlpu.edu.cn;xiangping@dicp.ac.cn
  • 基金资助:

    大连市科技局科技计划项目(No. 2011J21DW010)和辽宁省教育厅科学技术研究(No. L2010048)资助项目.

Progress on Unsymmetrical Hybrid Chiral Phosphine-phosphoramidite Ligands and Their Application in Asymmetric Catalytic Reactions

Hou Chuanjina,b, Liu Xiaoninga, Xia Yinga, Hu Xiangpingb   

  1. a School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034;
    b Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023
  • Received:2012-05-30 Revised:2012-07-17 Online:2012-12-25 Published:2012-07-18
  • Supported by:

    Project supported by the Planned Science and Technology Project of Dalian City (No. 2011J21DW010), and the Scientific Research Project of Department of Education of Liaoning Province (No. L2010048).

Unsymmetrical hybrid chiral phosphine-phosphoramidite ligands have the advantages of easy accessibility, modularity and stability toward air and moisture, which make them highly appealing for asymmetric catalysis. These ligands have been found widespread utility in asymmetric catalysis, such as hydrogenation, hydroformylation, allylic alkylation, hydrophosphorylation, [3+2] cycloaddition, 1,4-addition and 1,4-reduction. The types, synthesis and applications of chiral phosphine-phosphoramidite ligands are reviewed.

Key words: phosphine-phosphoramidite ligands, asymmetric hydrogenation, asymmetric hydroformylation, asymmetric allylic alkylation, asymmetric hydrophosphorylation, asymmetric [3+2] cycloaddition, asymmetric 1,4-addition and 1,4-reduction