Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2534-2552.DOI: 10.6023/cjoc201802022 Previous Articles     Next Articles



陈姝琪, 杨文, 姚永祺, 杨新, 邓颖颍, 杨定乔   

  1. 华南师范大学化学与环境学院 教育部环境理论化学重点实验室 广州 510006
  • 收稿日期:2018-02-24 修回日期:2018-05-15 发布日期:2018-06-07
  • 通讯作者: 杨定乔,
  • 基金资助:


Progress in Ruthenium-Catalyzed Asymmetric Hydrogenation of β-Keto Esters

Chen Shuqi, Yang Wen, Yao Yongqi, Yang Xin, Deng Yingying, Yang Dingqiao   

  1. Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006
  • Received:2018-02-24 Revised:2018-05-15 Published:2018-06-07
  • Contact: 10.6023/cjoc201802022
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172081, 21372090), the Natural Science Foundation of Guangdong Province (No. S2013020013091) and the City of Guangzhou Science and Technology Plan Projects (No. 156300018).

Ruthenium-catalyzed asymmetric hydrogenation of β-keto esters is one of the most effective methods for the synthesis of chiral β-hydroxy esters. The recent research progress in ruthenium-catalyzed asymmetric hydrogenation of β-keto esters is reviewed. Great attention was paid to the influences of chiral ligands, substrate structure, solvents and additives on the homogeneous asymmetric hydrogenation, as well as the influences of support materials and additives on the heterogeneous asymmetric hydrogenation.

Key words: ruthenium catalyst, β-keto ester, asymmetric hydrogenation, research progress