Chin. J. Org. Chem. ›› 0, Vol. ›› Issue (0): 0-0.DOI: 10.6023/cjoc201301009    



李英俊a, 于洋a, 许永廷b, 靳焜c, 罗潼川a, 邵昕a, 史相玲a, 吴疆红a   

  1. a 辽宁师范大学化学化工学院 大连116029;
    b 辽宁师范大学分析测试中心 大连116029;
    c 大连理工大学精细化工国家重点实验室 大连116012
  • 出版日期:2013-12-31 发布日期:2013-03-07
  • 通讯作者: 李英俊

Synthesis and Characterization of Dihydrazide Derivatives Containing Benzimidazole Ring

Li Yingjuna, Yu Yanga, Xu Yongtingb, Jin Kunc, Luo Tongchuana, Shao Xina, Shi Xianglinga, Wu Jianghonga   

  1. a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029;
    b Analysis and Inspection Center, Liaoning Normal University, Dalian 116029;
    c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012
  • Online:2013-12-31 Published:2013-03-07
  • Supported by:

    Project supported by the Natural Science Foundation of Liaoning Province (No. 20102126).

Ten novel dihydrazide derivatives containing benzimidazole ring (7a7j) were synthesized by (un)substituted phenol and chloroacetic acid as starting materials via a series of reactions. The structure of representative compound 7c was confirmed by its 1H NMR, 13C NMR, 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and variable-temperature 1H NMR spectra. The experimental results indicate that compound 7c in DMSO at room temperature exists in the tautomeric A and B isomers, and A isomer is dominant (87.65%). On the basis of the analytic results of compound 7c, 1H NMR spectra of other target compounds were also assigned and the content of dominant A isomer is in the range of 80.55%~89.90%.

Key words: dihydrazide, synthesis, characterization