Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (8): 2148-2156.DOI: 10.6023/cjoc201903068 Previous Articles     Next Articles

Special Issue: 陈茹玉先生诞辰100周年



程诚a, 孙孝斌a, 苗志伟a,b   

  1. a 南开大学化学学院 元素有机化学国家重点实验室 天津 300071;
    b 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2019-03-28 修回日期:2019-04-29 发布日期:2019-05-15
  • 通讯作者: 苗志伟
  • 基金资助:


Progress in Synthesis of Eight-Membered Cyclic Ethers

Cheng Chenga, Sun Xiaobina, Miao Zhiweia,b   

  1. a Research Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071;
    b Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2019-03-28 Revised:2019-04-29 Published:2019-05-15
  • Contact: 10.6023/cjoc201903068
  • Supported by:

    Project supported by the National Key Research and Development Program of China (No. 2016YFD0201200) and the Fundamental Research Funds for the Central Universities, Nankai University (No. 63191205).

Eight membered cyclic ether compounds are common structural motifs in natural products and bioactive molecules. The efficient synthesis of eight membered ethers has attracted wide attention for organic chemists. Compared with five-to seven-membered cyclic ethers, the synthesis of eight membered cyclic ethers is more challenging. In this paper, the synthetic methods for eight membered cyclic ethers by transition metal catalysis, ring expansion, retro-Claisen rearrangement, ring-closing metathesis, intramolecular amide enol alkylation and organic catalyzed tandem cyclization are reviewed.

Key words: eight-membered cyclic ethers, synthesis method, asymmetric synthesis