Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2655-2662.DOI: 10.6023/cjoc201903056 Previous Articles     Next Articles



钟良坤a,b, 江涛a, 张帆a, 付庆a, 刘幸海a, 许天明b, 丁成荣a, 陈杰c, 袁静c, 谭成侠a   

  1. a 浙江工业大学化学工程学院 杭州 310014;
    b 浙江省化工研究院有限公司 杭州 310023;
    c 浙江农林大学林业与生物技术学院 杭州 311300
  • 收稿日期:2019-03-26 修回日期:2019-04-19 发布日期:2019-05-15
  • 通讯作者: 袁静, 谭成侠;
  • 基金资助:


Synthesis and Insecticidal Activity of 3-Arylisoxazoline-pyrazole-5-carboxamide Derivatives

Zhong Liangkuna,b, Jiang Taoa, Zhang Fana, Fu Qinga, Liu Xinghaia, Xu Tianmingb, Ding Chengronga, Chen Jiec, Yuan Jingc, Tan Chengxiaa   

  1. a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;
    a Zhejiang Research Institute of Chemical Industry. Ltd., Hangzhou 310023;
    b School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300
  • Received:2019-03-26 Revised:2019-04-19 Published:2019-05-15
  • Contact: 10.6023/cjoc201903056;
  • Supported by:

    Project supported by the National Key Research and Development Plan (No. 2017YFD0200507).

A series of 3-arylisoxazoline-pyrazole-5-carboxamide derivatives derived from ethyl 5,5-dimethoxy-2,4-dioxopentanoate were designed, synthesized, and characterized by 1H NMR, 13C NMR and HRMS. The preliminary bioassay indicated that most title compounds exhibited positive potency against Mythimna separate (Walker) at 500 mg/L. At the concentration of 100 mg/L, three compounds were still moderately active against Mythimna separate (Walker) (lethal rate≈60%). At 500 mg/L, four compounds were also active against Aphis craccivora. The results indicated that the potential of these 3-arylisoxazoline-pyrazole-5-carboxamide derivatives can be utilized in insecticide research with further optimization.

Key words: arylisoxazoline, pyrazole-5-carboxamide, synthesis, insecticidal activity