Chin. J. Org. Chem. ›› 0, Vol. ›› Issue (0): 0-0.DOI: 10.6023/cjoc201301025    



王道林a, 董哲a, 徐姣b, 李帝a   

  1. a 辽宁省功能化合物合成与应用重点实验室, 渤海大学化学化工与食品安全学院 锦州 121003;
    b 黑龙江中医药大学佳木斯学院 佳木斯 154007
  • 出版日期:2013-12-31 发布日期:2013-03-07
  • 通讯作者: 王道林, 徐姣
  • 基金资助:


Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives

Wang Daolina, Dong Zhea, Xu Jiaob, Li Dia   

  1. a Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering & Food Safety, Bohai University, Jinzhou 121003;
    b Cosmetology Department, Heilongjiang University of Chinese Medicine,Jiamusi Institute, Jiamusi, 154007
  • Online:2013-12-31 Published:2013-03-07
  • Supported by:

    Project supported by the Science and Technology Department of Liaoning Province (No.2011220022), and the Innovation Talent Program of Heilongjiang University of Chinese Medicine.

An efficient and easy method for the synthesis of 1-(coumarin-3-carbonyl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene and 2-hydroxyaldehydes in the presence of ammonium acetate has been described. The structures of all target compounds have been confirmed by NMR, IR, MS spectra and elemental analysis, and the bioassay result indicated that some of the title compounds had relatively antibacterial activity.

Key words: azulene, guaiazulene, coumarin, synthesis, antibacterial activity