Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (11): 2430-2434.DOI: 10.6023/cjoc201305052 Previous Articles     Next Articles



王倩, 徐洲   

  1. 徐州医学院基础学院生化与化学综合实验室 徐州 221004
  • 收稿日期:2013-05-30 修回日期:2013-07-08 发布日期:2013-07-11
  • 通讯作者: 王倩
  • 基金资助:

    江苏省高校自然科学基金(No. 10KJB150018)资助项目.

Tetrabutylammonium Iodide-Catalyzed Phosphonation of sp3-C—H Bonds

Wang Qian, Xu Zhou   

  1. Experimental Center for Biochemistry and Chemistry Teaching, School of Basic Sciences, Xuzhou Medical College, Xuzhou 221004
  • Received:2013-05-30 Revised:2013-07-08 Published:2013-07-11
  • Supported by:

    Project supported by the Natural Science Foundation of Higher Education Institutions of Jiangsu Province (No. 10KJB150018).

Activation of sp3-C—H bonds and oxidative phosphonation of sp3-C—H bonds adjacent to a nitrogen atom of tertiary amine were catalyzed by tetrabutylammonium iodide (TBAI) with t-butylhydroperoxide (TBHP) as oxidant under mild reaction conditions. The safe, convenient, and environmentally benign process, as well as the broad substrate scope, low catalyst loading, high selectivity, short reaction time, and good yields make the protocol very practical.

Key words: sp3-C—H activation, oxidative coupling, phosphate, TBAI