Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2412-2427.DOI: 10.6023/cjoc201902012 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



杨振华, 祝家楠, 文彩月, 葛迎香, 赵圣印   

  1. 东华大学化学化工与生物工程学院 生态纺织教育部重点实验室 上海 201620
  • 收稿日期:2019-02-14 修回日期:2019-04-10 发布日期:2019-04-19
  • 通讯作者: 赵圣印
  • 基金资助:


Recent Advances in Functionalization of Double Bond Based on Maleimides

Yang Zhenhua, Zhu Jianan, Wen Caiyue, Ge Yingxiang, Zhao Shengyin   

  1. Key Laboratory of Science and Technology of Exo-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620
  • Received:2019-02-14 Revised:2019-04-10 Published:2019-04-19
  • Contact: 10.6023/cjoc201902012
  • Supported by:

    Project supported by the Shanghai Municipal Natural Science Foundation (No. 15ZR1401400) and the National Undergraduate Training Program for Innovation and Entrepreneurship in Donghua University (2018).

Maleimide, a common motif in a variety of natural alkaloids, has been extensively investigated due to its noteworthy biological activities and optical properties. Additionally, it can be transformed into many important heterocyclic frameworks such as succinimides, pyrrolidines, and 2-pyrrolidones. Thus, a great deal of attention has been focused on the development of new synthetic routes to access polyfunctionalized maleimides. In this article, the recent research progress in functionalization of double bond is reviewed based on maleimides according to Michael addition, oxidative coupling and cycloaddition reaction.

Key words: maleimide, Michael addition, oxidative coupling, cycloaddition reaction