Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (4): 647-661.DOI: 10.6023/cjoc201311043 Previous Articles     Next Articles



徐勤超, 金灿, 朱雪慧, 邢国文   

  1. 北京师范大学化学学院 北京 100875
  • 收稿日期:2013-11-26 修回日期:2013-12-12 发布日期:2013-12-23
  • 通讯作者: 邢国文
  • 基金资助:

    国家自然科学基金(No. 21272027)、北京市自然科学基金(No. 2122031)和北京市教育委员会共建项目专项资助项目.

Recent Progress in Fluorescent Probes for Pyrophosphate Based on Small Organic Molecules

Xu Qinchao, Jin Can, Zhu Xuehui, Xing Guowen   

  1. College of Chemistry, Beijing Normal University, Beijing 100875
  • Received:2013-11-26 Revised:2013-12-12 Published:2013-12-23
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272027), the Beijing Natural Science Foundation (No. 2122031), and the Beijing Municipal Commission of Education.

Pyrophosphate (PPi), a kind of important biological functional anion, plays crucial roles in life science, environmental science, medicine and chemical process. It has attracted extensive interests in supramolecular chemistry to design efficient fluorescent PPi sensors due to the simplicity and high sensitivity of fluorometric analysis. In this review, several kinds of strategies and theories of PPi fluorescent recognition and sensing are summarized, including off-on/on-off fluorescent response, excimer formation, hydrogen-bonding or electrostatic interactions and fluorescent indicator displacement assay. DPA-metal ion complexes, especially DPA-Zn2+ complex, have remarkable binding affinity and high selectivity for PPi. The chemosensing ensembles, consisting of DPA-Zn2+ complex and various fluorophores or fluorescent indicators, have been widely applied to the PPi fluorescent recognition and sensing.

Key words: fluorescent sensor, pyrophosphate, metal ion complex, excimer, indicator displacement