Synthesis of Molecular Tweezers Derived from Chenodeoxycholic Acid through Click Reaction and Their Recogniton Properties

doi:10.6023/cjoc201401042

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (6): 1110-1117.DOI: 10.6023/cjoc201401042 Previous Articles Next Articles

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通过点击化学方法合成鹅去氧胆酸类分子钳及其识别性能研究

赵志刚, 王晓红, 石治川, 程玉宇

西南民族大学化学与环境保护工程学院成都 610041

收稿日期:2014-01-25 修回日期:2014-03-10 发布日期:2014-04-15
通讯作者: 赵志刚 E-mail:zzg63129@163.com
基金资助:
四川省科技支撑计划基金（No. 2012SZ0160）和国家外专局基金（No. 2013-32）资助项目.

Synthesis of Molecular Tweezers Derived from Chenodeoxycholic Acid through Click Reaction and Their Recogniton Properties

Zhao Zhigang, Wang Xiaohong, Shi Zhichuan, Cheng Yuyu

College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041

Received:2014-01-25 Revised:2014-03-10 Published:2014-04-15
Supported by:
Project supported by the Science and Technology Department of Sichuan Province (No. 2012SZ0160) and the National Foreign Expert Bureau (No. 2013-32).

Twelve novel chenodeoxycholic acid-based molecular tweezer metal receptors containing 1,2,3-triazole moieties have been designed and synthesized using click chemistry method. The target compounds were characterized by ¹H NMR, IR, MS spectra and elemental analysis. Their binding properties were examined by UV-Vis spectra titration. The results indicate that these molecular tweezers showed high selectivity and affinity for Hg²⁺ ion.

Key words: cation recognition, molecular tweezer, click chemistry, 1,2,3-triazole, chenodeoxycholic acid

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Zhao Zhigang, Wang Xiaohong, Shi Zhichuan, Cheng Yuyu. Synthesis of Molecular Tweezers Derived from Chenodeoxycholic Acid through Click Reaction and Their Recogniton Properties[J]. Chin. J. Org. Chem., 2014, 34(6): 1110-1117.

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通过点击化学方法合成鹅去氧胆酸类分子钳及其识别性能研究

Synthesis of Molecular Tweezers Derived from Chenodeoxycholic Acid through Click Reaction and Their Recogniton Properties

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