Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (7): 1268-1276.DOI: 10.6023/cjoc201404010 Previous Articles     Next Articles



唐敏a,b, 邢栋a,b, 蔡茂强a,b, 胡文浩a,b   

  1. a 华东师范大学上海分子治疗与新药创制工程技术研究中心 上海 200062;
    b 华东师范大学化学系 上海 200062
  • 收稿日期:2014-04-03 修回日期:2014-05-21 发布日期:2014-06-09
  • 通讯作者: 胡文浩
  • 基金资助:


Diazo Compounds-Involved Catalytic Asymmetric Multicomponent Reactions

Tang Mina,b, Xing Donga,b, Cai Maoqianga,b, Hu Wenhaoa,b   

  1. a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062;
    b Department of Chemistry, East China Normal University, Shanghai 200062
  • Received:2014-04-03 Revised:2014-05-21 Published:2014-06-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21125209, 21332003), the Ministry of Science and Technology of China (No. 2011CB808600) and the Science and Technology Commission of Shanghai Municipality (No. 12JC1403800).

This accounts covers the recent advances in diazo compounds-involved catalytic asymmetric multicomponent reactions developed by our research group. Based on the electrophilic trapping of active oxonium ylides, ammonium ylides or zwitterionic intermediates that generated from diazo compounds via metal carbenes, an array of catalytic asymmetric multicomponent reactions have been developed. Cooperative catalytic strategies have been applied to control enantioselectivity of the reactions. These transformations offer efficient and powerful strategies for the synthesis of polyfunctional chiral molecules

Key words: diazo compound, metal carbene, catalytic asymmetric, multicomponent reaction, cooperative catalysis