Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (4): 917-921.DOI: 10.6023/cjoc201410037 Previous Articles     Next Articles



杨鑫, 孙中强, 邓云霞, 邵志宇   

  1. 东华大学化学化工与生物工程学院 上海 201620
  • 收稿日期:2014-10-28 修回日期:2014-11-23 发布日期:2014-12-09
  • 通讯作者: 邵志宇
  • 基金资助:

    中央高校基本科研业务费专项资金(Nos. 13D110513, 2232012D3-03)资助项目.

Research of Rearrangement Products of Gambogic Acid

Yang Xin, Sun Zhongqiang, Deng Yunxia, Shao Zhiyu   

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620
  • Received:2014-10-28 Revised:2014-11-23 Published:2014-12-09
  • Supported by:

    Project supported by the Fundamental Research Funds for the Central Universities (Nos. 13D110513, 2232012D3-03).

Gambogic acid derivatives possess potent anti-tumor activities against various cancer cell lines. In a search for new anti-tumor organic compounds, rearrangement reaction of gambogic acid was explored. After microwave irradiation under acidic condition, two rearrangement products were isolated and their structures were determined unambiguously by spectroscopic techniques. Both of them were screened for their cytotoxicities against A549, HCT116 and MDA-MB-231, and showed high inhibitory effects on the cell lines.

Key words: gambogic acid, rearrangement reaction, spectroscopy, cytotoxicity