Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 633-637.DOI: 10.6023/cjoc201410045 Previous Articles     Next Articles



许恺, 沈冲, 盛卫坚, 单尚, 贾义霞   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2014-10-31 修回日期:2015-01-08 发布日期:2015-02-11
  • 通讯作者: 贾义霞
  • 基金资助:

    国家自然科学基金(No. 21372202)、新世纪优秀人才支持计划(No. NCET-12-1086)、浙江省杰出青年科学基金(No. R14B020005)资助项目.

Copper-Catalyzed Direct Benzylation of β-Ketoesters with N-Tosylhydrazones

Xu Kai, Shen Chong, Sheng Weijian, Shan Shang, Jia Yixia   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2014-10-31 Revised:2015-01-08 Published:2015-02-11
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372202), the New Century Excellent Talents in University (No. NCET-12-1086), and the Zhejiang Natural Science Fund for Distinguished Young Scholars (No. R14B020005).

A simple and efficient method for the benzylation of β-ketoesters by employing copper salt as a catalyst was developed. The mild reaction system and a wide range of substrates with high yields make the protocol very practical. It provides a new route for the synthesis of α-benzyl-β-ketoesters.

Key words: CuI, N-tosylhydrazones, β-ketoesters, benzylation