Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 625-632.DOI: 10.6023/cjoc201501037 Previous Articles     Next Articles


陈斌, 于丛军, 张国柱   

  1. 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2015-01-27 修回日期:2015-03-03 发布日期:2015-03-04
  • 通讯作者: 张国柱
  • 基金资助:


A Novel Method to Prepare Multisubstituted Pyrazoles

Chen Bin, Yu Congjun, Zhang Guozhu   

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032
  • Received:2015-01-27 Revised:2015-03-03 Published:2015-03-04
  • Supported by:

    Project supported by the Foundation of Shanghai Institute of Organic Chemistry, Chinese Academy of Science.

This paper reports a new strategy to construct multisubstituted pyrazoles from hydrazine and 1,3-diketone which is generated through α-oxo gold carbene using readily available propargyl alcohol. The carbene formation and C—C bond migration could be applied in a tandem process, connected by a carbene cyclization, leading to complex diketone products.

Key words: gold catalysis, pyrazole, gold carbene, polycyclic, tandem process