Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (4): 1435-1443.DOI: 10.6023/cjoc202211021 Previous Articles     Next Articles



张紫婵, 孙洋, 华晟, 徐宝琳, 张敏, 赵勤*(), 郑丹丹, 王杨, 鞠剑峰*(), 石玉军, 戴红*()   

  1. 南通大学化学化工学院 南通 226019
  • 收稿日期:2022-11-16 修回日期:2022-12-23 发布日期:2023-01-05
  • 通讯作者: 赵勤, 鞠剑峰, 戴红
  • 作者简介:
  • 基金资助:
    国家自然科学基金(22177057); 南通市科技计划(MS2202024)

Synthesis and Insecticidal Activity of Novel Pyrazole Amides Containing an Isoxazole Moiety

Zichan Zhang, Yang Sun, Sheng Hua, Baolin Xu, Min Zhang, Qin Zhao(), Dandan Zheng, Yang Wang, Jianfeng Ju(), Yujun Shi, Hong Dai()   

  1. College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
  • Received:2022-11-16 Revised:2022-12-23 Published:2023-01-05
  • Contact: Qin Zhao, Jianfeng Ju, Hong Dai
  • About author:
    These authors contributed equally to this work.
  • Supported by:
    National Natural Science Foundation of China(22177057); Science and Technology Project Fund of Nantong City(MS2202024)

Sixteen novel pyrazole amide compounds containing an isoxazole unit were synthesized through introducing an isoxazole moiety to pyrazole amide molecules based on the structure of chlorantraniliprole. The structures of the designed compounds were characterized with 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay showed that most of the target compounds exhibited 100% insecticidal activities against Mythimna separata at the dosage of 500 μg/mL. Three compounds had 80%~100% mortality rate towards M. separata at the dosage of 100 μg/mL, and three compounds still possessed 40%~50% mortality rate against M. separata when the dosage was lowered to 20 μg/mL. Three compounds displayed 100% insecticidal activities towards Aphis medicaginis at 500 μg/mL, and still showed good insecticidal activities against A. medicaginis with 70%~100% at 100 μg/mL. In addition, two compounds demonstrated 90%~100% mortality rates towards Tetranychus cinnabarinus at 500 μg/mL.

Key words: isoxazole, pyrazole amide, synthesis, insecticidal activity