Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 528-538.DOI: 10.6023/cjoc201502017 Previous Articles     Next Articles



王英杰a, 张振锋b, 张万斌a,b   

  1. a 上海交通大学化学化工学院 上海 200240;
    b 上海交通大学药学院 上海 200240
  • 收稿日期:2015-02-09 修回日期:2015-02-28 发布日期:2015-03-03
  • 通讯作者: 张万斌
  • 基金资助:

    国家自然科学基金(No. 21202096)资助项目.

Asymmetric Hydrogenation of Cyclic Dehydroamino Acids and Their Derivatives

Wang Yingjiea, Zhang Zhenfengb, Zhang Wanbina,b   

  1. a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240;
    b School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2015-02-09 Revised:2015-02-28 Published:2015-03-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21202096).

Chiral cyclic amino acids, possessing the unique structure and special properties, can be found in various chiral drugs and chiral catalysts as structural motifs. Transition-metal-catalyzed asymmetric hydrogenation, which has the advantages of high efficiency, environmental friendliness and atom economy, becomes the preferred method for the syntheses of such compounds. The related works on this field are reviewed for the first time in this paper. The catalytic asymmetric hydrogenation of various types of cyclic α- and β-dehydroamino acids and their derivatives is introduced, and the advantages and disadvantages of different kinds of transition-metal catalysts (including complexes of Ru, Rh, and Ir) are discussed. Thus a perspective is proposed for the future development.

Key words: cyclic amino acids, cyclic dehydroamino acids, asymmetric hydrogenation, Ru-catalyzed, Rh-catalyzed, Ir-catalyzed