Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (10): 2199-2204.DOI: 10.6023/cjoc201505033 Previous Articles     Next Articles



李建晓a, 张振明a, 李春生a, 罗维b, 杨少容a   

  1. a 华南理工大学化学与化工学院 广州 510640;
    b 华南理工大学分析测试中心 广州 510640
  • 收稿日期:2015-05-21 修回日期:2015-06-05 发布日期:2015-06-16
  • 通讯作者: 杨少容
  • 基金资助:

    国家自然科学基金(Nos. 21102047, 31101221)和中国博士后科学基金(No. 2015M572303)资助项目.

Palladium-Catalyzed Intermolecular Carboesterification of Alkynoic Acids with Alkenes

Li Jianxiaoa, Zhang Zhenminga, Li Chunshenga, Luo Weib, Yang Shaoronga   

  1. a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640;
    b Analytical and Testing Center, South China University of Technology, Guangzhou 510640
  • Received:2015-05-21 Revised:2015-06-05 Published:2015-06-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21102047, 31101221) and the China Postdoctoral Science Foundation (No. 2015M572303).

An efficient and mild palladium-catalyzed cascade carboesterification has been developed to afford functionalized α-methylene-γ-lactones in moderate to good yields with high regio-and diastereo-selectivities. Their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS. Furthermore, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active α-methylene-γ-lactones.

Key words: palladium-catalyzed, ionic liquids, alkynoic acids, alkenes, carboesterification