Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (10): 3152-3166.DOI: 10.6023/cjoc202207036 Previous Articles     Next Articles

Special Issue: 不对称催化专辑



王豪锐, 叶萌春*()   

  1. 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2022-07-26 修回日期:2022-10-05 发布日期:2022-11-02
  • 通讯作者: 叶萌春
  • 基金资助:
    国家自然科学基金(21871145); 国家自然科学基金(22188101); 可持续化学转化海河实验室和南开大学新物质科学中心(63181206)

Research Advance on Enantioselective Transition Metal-Catalyzed Hydroacylation Reactions

Haorui Wang, Mengchun Ye()   

  1. State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2022-07-26 Revised:2022-10-05 Published:2022-11-02
  • Contact: Mengchun Ye
  • Supported by:
    National Natural Science Foundation of China(21871145); National Natural Science Foundation of China(22188101); Haihe Laboratory of Sustainable Chemical Transformations and the “Frontiers Science Center for New Organic Matter”, Nankai University(63181206)

Transition metal-catalyzed hydroacylation reaction of aldehydes with π-unsaturated compounds provides an economical and efficient method for the construction of C—C bonds, not only allowing readily available starting materials to be used as substrates, but also featuring high atom and step economy. Therefore, the reaction has received continuous and extensive attention during the past several decades. The advances on enantioselective transition metal-catalyzed hydroacylation reactions are summarized, focusing on reaction types, asymmetric strategies and reaction mechanisms.

Key words: transition metal catalysis, hydroacylation, asymmetric catalysis, aldehydes, alkenes