Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (11): 2723-2728.DOI: 10.6023/cjoc201603007 Previous Articles     Next Articles



孟瑾, 杜利月, 郭留城   

  1. 漯河医学高等专科学校药学系 河南 漯河 462002
  • 收稿日期:2016-03-06 修回日期:2016-07-21 发布日期:2016-08-10
  • 通讯作者: 孟瑾

Synthesis of Arylnaphthalene Lignan Lactones

Meng Jin, Du Liyue, Guo Liucheng   

  1. Department of Pharmacy, Luohe Medical College, Luohe, Henan 462002
  • Received:2016-03-06 Revised:2016-07-21 Published:2016-08-10

Arylnaphthalene lignan lactones, widely distributed in plants, are a class of natural products containing the phenyl-naphthyl skeleton. These compounds have attracted considerable attention of many scientists for decades because of their wide biological activities. In this study, a convenient method is presented for the multiple parallel synthesis of arylnaphthalene lignans. With vanillic acid as starting material, six arylnaphthalene nature products were prepared in the process with 8 steps, via Diels-Alder reaction, Suzuki reaction and Fetizon oxidation as the key reactions.

Key words: Arylnaphthalene lignan lactones, Diels-Alder reaction, Suzuki-Miyaura coupling, Fetizon oxidation