Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (10): 2333-2343.DOI: 10.6023/cjoc201605009 Previous Articles     Next Articles



敖宇飞a,b, 王其强a, 王德先a,b   

  1. a 中国科学院化学研究所 北京分子科学国家实验室 中国科学院分子识别与功能重点实验室 北京 100190;
    b 中国科学院大学 北京 100049
  • 收稿日期:2016-05-09 修回日期:2016-06-11 发布日期:2016-06-20
  • 通讯作者: 敖宇飞,
  • 基金资助:


Biocatalytic Desymmetrization of Dinitriles in Organic Synthesis

Ao Yufeia,b, Wang Qiqiangaa, Wang Dexianaa,b   

  1. a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190;
    b University of Chinese Academy of Sciences, Beijing 100049
  • Received:2016-05-09 Revised:2016-06-11 Published:2016-06-20
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21502202).

In comparison with the chemical hydration and hydrolysis of nitriles, which usually involves harsh reaction condi-tions and low selectivity, biocatalytic desymmetrizations of prochiral or meso nitriles are highly efficient, highly enantioselective and environmentally benign. Therefore, biocatalysis and biotransformation has offered an attractive and unique protocol for the enantioselective synthesis of polyfunctionalized organic compounds that are not readily obtainable by other methods. This review summarizes the biocatalytic desymmetrization of prochiral nitriles including glutaronitriles, malonitriles and meso cyclic dinitriles during the past two decades.

Key words: desymmetrization, biotransformations, dinitriles