Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (1): 103-109.DOI: 10.6023/cjoc201606034 Previous Articles     Next Articles



康娟, 黄丹凤, 王克虎, 苏瀛鹏, 胡雨来, 常青   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2016-06-22 修回日期:2016-09-12 发布日期:2016-09-19
  • 通讯作者: 黄丹凤, 胡雨来;
  • 基金资助:

    国家自然科学基金(Nos. 21262031,21462037)资助项目.

Synthesis of α-Trifluoromethyl-α-hydroxyl Weinreb Amides

Kang Juan, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai, Chang Qing   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2016-06-22 Revised:2016-09-12 Published:2016-09-19
  • Supported by:

    Project supported by the National Natural Science Foundation of China(Nos. 21262031, 21462037).

Selective trifluoromethylation of α-oxo-Weinreb amides was explored using trimethyl(trifluoromethyl) silane as fluorinating reagent.A series of α-trifluoromethyl-α-hydroxyl Weinreb amides were successfully synthesized and their reaction with organometallic reagents was investigated.

Key words: trifluoromethylation, trimethyl(trifluoromethyl) silane, α-trifluoromethyl-α-hydroxyl Weinreb amides, Grignard reagents