Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF3-Sources

doi:10.6023/cjoc201810033

Abstract

Organic molecules containing trifluoromethyl groups often exhibit unique physical and chemical properties, and have found extensive applications. Trifluoroacetic acid and its derivatives have advantages including low cost, ready availability and high stability. Furthermore, CO₂ is the byproduct. Therefore, trifluoroacetic acid and its derivatives are ideal trifluoromethylating reagents, and have great application potentials. The progress of trifluoromethylation reactions using trifluoroacetic acid and its derivatives as CF₃-sources is reviewed, including the reactions of C-X (X=Br and I), C-H, and C=X (X=C, O). The mechanisms are also introduced.

Key words: trifluoroacetic acid, CF₃-sources, trifluoromethylation reaction, C-H activation

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Ji Xiaoming, Shi Guangfa, Zhang Yanghui. Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF₃-Sources[J]. Chin. J. Org. Chem., 2019, 39(4): 929-939.

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以三氟乙酸及其衍生物为三氟甲基源的三氟甲基化反应研究进展

Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF₃-Sources

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