Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1701-1713.DOI: 10.6023/cjoc201702011 Previous Articles     Next Articles



戴一a,c, 仲飞b   

  1. a. 安徽新华学院药学院 合肥 230088;
    b. 安徽医科大学第一附属医院肿瘤科 合肥 230022;
    c. 中国科学技术大学化学系 合肥 230026
  • 收稿日期:2017-02-09 修回日期:2017-03-07 发布日期:2017-03-17
  • 通讯作者: 戴一
  • 基金资助:


Advances in the Study of Structural Modification and Biological Activities of Oridonin

Dai Yia,c, Zhong Feib   

  1. a. Pharmacology College, Anhui Xinhua University, Hefei 230088;
    b. Department of Oncology, First Affiliated Hospital, Anhui Medical University, Hefei 230022;
    c. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Received:2017-02-09 Revised:2017-03-07 Published:2017-03-17
  • Contact: 10.6023/cjoc201702011
  • Supported by:

    Project supported by the Key National Natural Science Foundation of Department of Education of Anhui Province (No.KJ2016A301).

Oridonin,an ent-kaurane diterpenoid,is found in the Chinese herb Rabdosia rubescens and some related species, and has various biological activities such as anti-tumor,anti-microbial,anti-inflammatory,and so on.This review provides an overview of the multifunctional effects of the structural modification of oridonin since 2000,suggesting that it may be effective choice for improving pharmacological activities.

Key words: oridonin, structural modification, anti-cancer activity, anti-mycobacterial activity