Advances in Application of Marine Bioactive Peptides in Drug Development

doi:10.6023/cjoc201612062

Abstract

The ocean is the most resource-rich area on earth. The living environment of marine life is complicated, so that they form a special structure of the active substances. Coupled with the progress of science and technology, people are increasingly concerned about how to find new active substances from marine life, which makes the marine bioactive peptide is widely concerned. Bioactive peptides have a variety of activities, the study shows that these substances have antioxidant, antihypertensive, anti-virus and anti-tumor activity. It has the advantages of low toxicity, high targeting specificity and strong biological activity. At present, some of bioactive peptides extracted from sea cucumbers, conus, ascidians, sponges, marine fungi, molluscs, or analogues derived from these compounds have entered the market or clinical stage. The current research status of marine bioactive peptides is reviewed including their source, synthetic method, chemical structure, activity, mechanism, clinical efficacy and safety. Research prospects in this field are discussed.

Key words: marine peptide, bioactivity, pharmaceutical, clinical trial

Cite this article

Lu Wenyu, Yu Wenjing, Sun Dequn. Advances in Application of Marine Bioactive Peptides in Drug Development[J]. Chin. J. Org. Chem., 2017, 37(7): 1681-1700.

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海洋生物活性肽在药物研发中的应用进展