Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2175-2186.DOI: 10.6023/cjoc201705001 Previous Articles     Next Articles



廖富民a, 余金生a, 周剑a,b   

  1. a 华东师范大学化学与分子工程学院 绿色化学与化工过程绿色化上海市重点实验室 上海 200062;
    b 中国科学院上海有机化学研究所 金属有机国家重点实验室 上海 200032
  • 收稿日期:2017-05-01 修回日期:2017-06-28 发布日期:2017-07-07
  • 通讯作者: 余金生, 周剑;
  • 基金资助:


Recent Advances in the Highly Stereoselective Synthesis of Tri-or Tetra-substituted Monofluoroalkenes

Liao Fumina, Yu Jinshenga, Zhou Jiana,b   

  1. a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2017-05-01 Revised:2017-06-28 Published:2017-07-07
  • Contact: 10.6023/cjoc201705001;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21472049).

Monofluoroalkenes have found applications in many areas of research, including the design and development new materials and drug. The highly stereoselective synthesis of this privileged structural motif has attracted great synthetic attention. This review summarizes recent progresses in highly stereoselective synthesis of monofluoroalkenes from aldehydes, ketones and diazo compounds, other substrates such as alkynes, alkenyl metallic species and alkenes are also included. The advantages and disadvantages of different methods are discussed.

Key words: monofluoroalkene, stereoselective synthesis, aldehyde and ketone, diazo compound