Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2859-2872.DOI: 10.6023/cjoc201705011 Previous Articles     Next Articles



张甲勇b, 木尼热·阿布都克力木a, 苗志伟a,b   

  1. a 喀什大学化学与环境科学学院 新疆喀什 844006;
    b 南开大学化学学院 元素有机化学研究所 天津 300071
  • 收稿日期:2017-05-07 修回日期:2017-06-28 发布日期:2017-07-07
  • 通讯作者: 苗志伟
  • 基金资助:


Research Progress of Organophosphine-Catalyzed Annulation Reaction of Electron-Deficient Alkynoates or Ynones

Zhang Jiayongb, Abudukeremu Muniraa, Miao Zhiweia,b   

  1. a College of Chemistry and Environmental Sciences, Kashgar University, Kashgar 844006;
    b College of Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:2017-05-07 Revised:2017-06-28 Published:2017-07-07
  • Contact: 10.6023/cjoc201705011
  • Supported by:

    Project supported by the Committee of Science and Technology of Xinjiang (No. 2016D01A016).

Organophosphine catalyst is a kind of strong nucleophilic Lewis base. It is widely used in the field of organic synthesis. An active and important zwitterion intermediate can be generated via nucleophilic addition of the tertiary phosphine to electron-deficient alkynoates or ynones and achieves further transformation, including isomerization, α-, β-, γ-addition reactions and[2+2],[3+2],[4+2] cycloaddition reactions. Varieties of pharmaceuticals, natural products and other bioactive moleculars could be efficiently synthesized through organophosphine-catalyzed cycloaddition reaction. The research of organ-ophosphine-catalyzed cycloaddition reaction of electron-deficient alkynoates or ynones has gained more attention. The recent development of organophosphine-catalyzed cycloaddition reaction of electron-deficient alkynoates or ynones is summarized.

Key words: tertiary organophosphine-catalyzed reaction, electron-deficient alkynoates (ynones), cycloaddition reaction