Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 86-94.DOI: 10.6023/cjoc201708049 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑 元素有机化学合辑2018-2019



乔辉杰a, 孙素颜a, 康建勋a, 杨帆a, 吴豫生b,c, 吴养洁a   

  1. a 郑州大学化学与分子工程学院 河南省化学生物与有机化学重点实验室河南省高校应用化学重点实验室 郑州 450052;
    b 郑州泰基鸿诺医药股份有限公司 郑州 450052;
    c 河南省新药创制与药物安全性评价协同创新中心 郑州 450001
  • 收稿日期:2017-08-23 修回日期:2017-09-20 发布日期:2017-09-26
  • 通讯作者: 杨帆, 吴豫生, 吴养洁;;
  • 基金资助:


Copper-Catalyzed Decarboxylative Coupling of Alkenyl Acids with P(O)H Compounds at Room Temperature

Qiao Huijiea, Sun Suyana, Kang Jianxuna, Yang Fana, Wu Yushengb,c, Wu Yangjiea   

  1. a College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052;
    b Tetranov Biopharm, LLC., Zhengzhou 450052;
    c Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001
  • Received:2017-08-23 Revised:2017-09-20 Published:2017-09-26
  • Contact: 10.6023/cjoc201708049;;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21102134, 21172200).

A simple and mild protocol for the copper-catalyzed decarboxylative coupling of alkenyl acids with P(O)H compounds was developed, thus providing a facile route to the vinylphosphorus compounds. Moreover, the reaction could also afford β-ketophosphorus compounds as the major products in air using oxygen as an oxidant. In addition, the remarkable features of these two types of reactions include excellent reaction chemoselectivity, good functional group tolerance and mild reaction conditions (e.g., cheap oxidant, ligand-free condition and room temperature).

Key words: copper catalysis, decarboxylative coupling, alkenyl acids, P(O)H compounds