Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 162-170.DOI: 10.6023/cjoc201708066 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑




  1. 郑州大学化学与分子工程学院 郑州 450052
  • 收稿日期:2017-08-31 修回日期:2017-09-11 发布日期:2017-10-24
  • 通讯作者: 王敏灿
  • 基金资助:


Enantioselective Analysis: Logic of Chiral Ligand Design for Asymmetric Addition of Diethylzinc to Benzaldehyde

Wang Mincan   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052
  • Received:2017-08-31 Revised:2017-09-11 Published:2017-10-24
  • Contact: 王敏灿
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (Nos. 21272216, 20972140).

A detailed logic-guided approach towards chiral ligands design is described via the enantioselective analysis of the dynamic conformational behaviors of catalyst, which is based on a mathematical relationship between conformations and enantioselectivity, for asymmetric addition of diethylzinc to benzaldehyde. Following this logic thought, 94 examples, almost all highly enantioselective β-aminoalcohol ligands reported, can be rationally devised by the logic control of the dynamic conformational behaviors of the catalyst from the simplest β-aminoalcohol with one single chiral center as starting point.

Key words: enantioselective analysis, conformational control, rational design, chiral ligand, diethylzinc