Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (07): 1355-1368.DOI: 10.6023/cjoc201211036 Previous Articles     Next Articles

Reviews

亚胺的不对称催化氢化研究进展

王东a, 侯传金a,b, 陈丽凤a, 刘小宁a, 安庆大a, 胡向平b   

  1. a 大连工业大学轻工与化学工程学院 大连 116034;
    b 中国科学院大连化学物理研究所 大连 116023
  • 收稿日期:2012-11-20 修回日期:2012-12-15 发布日期:2013-01-09
  • 通讯作者: 侯传金, 安庆大, 胡向平 E-mail:houcj@dlpu.edu.cn;anqingda@dlpu.edu.cn;xiangping@dicp.ac.cn
  • 基金资助:

    大连市科技局科技计划(No. 2011J21DW010)和辽宁省教育厅科学技术研究(No. L2010048)资助项目

Progress on the Catalytic Asymmetric Hydrogenation of Imines

Wang Donga, Hou Chuanjina,b, Chen Lifenga, Liu Xiaoninga, An Qingdaa, Hu Xiangpingb   

  1. a School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034;
    b Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023
  • Received:2012-11-20 Revised:2012-12-15 Published:2013-01-09
  • Supported by:

    Project supported by the Planned Science and Technology Project of Dalian City (No. 2011J21DW010), and the Scientific Research Project of Department of Education of Liaoning Province (No. L2010048)

Chiral amines are important synthetic intermediates in the preparation of many physiologically active compounds. Catalytic asymmetric hydrogenation of prochiral imines represents one of the most direct and convenient route to chiral amines and their derivatives. During the past two decades, significant progress has been made in the asymmetric hydrogenation of imines. Many highly enantioselective chiral catalysts have been disclosed, some new methods and strategies have been developed, and some challenging imines substrates have been efficiently hydrogenated in high enantioselectivities. Despite these achievements, catalytic asymmetric hydrogenation of imines still have challenges of low reactivity, narrow substrate scope, harsh hydrogenation conditions and difficulty in catalyst reuse. Therefore, development of new catalyst system with high reactivity and enantioselectivity as well as environmental friendship in the asymmetric hydrogenation of imines is of great interest. This review presents a brief overview on the progress in catalytic asymmetric hydrogenation of cyclic and acyclic imines.

Key words: imines, asymmetric catalysis, hydrogenation, chiral ligand