Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 692-697.DOI: 10.6023/cjoc201709039 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019



景丽a, 金辉a, 管玫b, 武潇华a, 王乾韬a, 吴勇a   

  1. a 四川大学华西药学院 成都 610041;
    b 四川大学华西医院 成都 610041
  • 收稿日期:2017-09-22 修回日期:2017-10-30 发布日期:2017-11-15
  • 通讯作者: 王乾韬,;吴勇,;
  • 基金资助:


Metal-Free Oxidation of Thiols by N-Fluorobenzenesulfonimide: A Rapid and Efficient Method to Synthesize Disulfides

Jing Liaa, Jin Huiaa, Guan Meibb, Wu Xiaohuaaa, Wang Qiantaoaa, Wu Yongaa   

  1. a Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 61004;
    b West China Hospital, Sichuan University, Chengdu 610041
  • Received:2017-09-22 Revised:2017-10-30 Published:2017-11-15
  • Contact: 10.6023/cjoc201709039;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81373259, 81573286).

A simple and rapid method is developed for the oxidation of thiols to the corresponding disulfides using N-fluorobenzenesulfonimide (NFSI) as the oxidant without any contamination by over oxidation. The synthetic protocol for disulfide bond formation proceeded efficiently under external base-and metal-free conditions with the advantages of simple operation, mild reaction conditions as well as short reaction times.

Key words: N-fluorobenzenesulfonimide, oxidation, disulfide