Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 112-117.DOI: 10.6023/cjoc201711001 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑



郭真, 谢明胜, 韩瑞杰, 渠桂荣, 郭海明   

  1. 河南师范大学化学化工学院 新乡 453007
  • 收稿日期:2017-11-01 修回日期:2017-11-19 发布日期:2017-11-21
  • 通讯作者: 渠桂荣, 郭海明;
  • 基金资助:


Ag-Catalyzed Monofluoromethylation of Purin-9-yl Allenes with Fluorobis(phenylsulfonyl)methane

Guo Zhen, Xie Mingsheng, Han Ruijie, Qu Guirong, Guo Haiming   

  1. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007
  • Received:2017-11-01 Revised:2017-11-19 Published:2017-11-21
  • Contact: 10.6023/cjoc201711001;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. U1604283, 21402041), the Plan for Scientific Innovation Talent of Henan Province (No. 164200510008), the China Postdoctoral Science Foundation Funded Project (No. 2016M592293), the Program for Innovative Research Team in Science, Technology in University of Henan Province (No. 15IRTSTHN003) and the Program of Introducing Talents of Discipline to Universities (111 Project, No. D17007).

The monofluoromethylation of purin-9-yl allenes with fluorobis(phenylsulfonyl)methane has been achieved. With AgF (3 mol%) as the catalyst, the fluorobis(phenylsulfonyl)methylated adducts could be afforded in excellent yields. The monofluoromethylation exhibited high chemoselectivities and E-selectivies. Meanwhile, the monofluoromethylation of purin-9-yl allenes with fluorobis(phenylsulfonyl)methane provided a useful route to construct fluorinated acyclic nucleoside analogues.

Key words: monofluoromethylation, purin-9-yl allene, fluorobis(phenylsulfonyl)methane