Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 1949-1962.DOI: 10.6023/cjoc201803013 Previous Articles     Next Articles

Reviews

过渡金属催化的基于季铵盐C-N键断裂的偶联反应研究进展

李刚a,b, 陈烨a, 夏纪宝b   

  1. a 贵州大学化学与化工学院 贵阳 550025;
    b 中国科学院兰州化学物理研究所苏州研究院 羰基合成与选择氧化国家重点实验室 兰州 730000
  • 收稿日期:2018-03-12 修回日期:2018-04-08 出版日期:2018-08-25 发布日期:2018-04-27
  • 通讯作者: 陈烨, 夏纪宝 E-mail:jibaoxia@licp.cas.cn;ychen19@gzu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21702212,21772208,21402089)和江苏省自然科学基金(No.BK20161260)资助项目.

Progress on Transition-Metal-Catalyzed Cross-Coupling Reactions of Ammonium Salts via C-N Bond Cleavage

Li Ganga,b, Chen Yea, Xia Jibaob   

  1. a School Chemistry of Chemical Engineering, Guizhou University, Guiyang 550025;
    b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics(LICP), Chinese Academy of Sciences, Lanzhou 730000
  • Received:2018-03-12 Revised:2018-04-08 Online:2018-08-25 Published:2018-04-27
  • Contact: 10.6023/cjoc201803013 E-mail:jibaoxia@licp.cas.cn;ychen19@gzu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21702212, 21772208, 21602230) and the Natural Science Foundation of Jiangsu Province (No. BK20161260).

Amines containing carbon-nitrogen (C-N) bonds are widely distributed in natural products, drug molecules and functional materials. C-N bonds are one of the most abundant and inert bonds in organic molecules. Selective cleavage of C-N bonds to construct carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds represents a new synthetic method in organic synthesis. It is difficult for the direct cleavage of C-N bond. Ammonium salts are a series of stable compounds easily obtained from amines. The recent progress of transition-metal-catalyzed cross-coupling reactions via C-N bond cleavage using ammonium salts as starting materials is summerized.

Key words: transition-metal-catalysis, ammonium salt, cross-coupling reaction, C-N bond cleavage