Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (4): 1489-1497.DOI: 10.6023/cjoc202009029 Previous Articles     Next Articles



李清寒1,*(), 罗瑞强1, 吴川1, 肖红柳1, 郭少鹏1, 张志豪1, 黄哲耀1, 周林1   

  1. 1 西南民族大学化学与环境保护工程学院 成都 610041
  • 收稿日期:2020-09-12 修回日期:2020-10-13 发布日期:2020-11-04
  • 通讯作者: 李清寒
  • 基金资助:
    西南民族大学中央高校基本科研业务费(2018NZD06); 四川省科技厅科技支撑计划(2015NZ0033)

Research Progress of Cross-Coupling Reactions of Alkylaluminums with Electrophiles Reagents

Qinghan Li1,*(), Ruiqiang Luo1, Chuan Wu1, Hongliu Xiao1, Shaopeng Guo1, Zhihao Zhang1, Zheyao Huang1, Lin Zhou1   

  1. 1 College of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu 610041
  • Received:2020-09-12 Revised:2020-10-13 Published:2020-11-04
  • Contact: Qinghan Li
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    Fundamental Research Funds for the Central Universities, the Southwest Minzu University(2018NZD06); Sichuan Provincial Department of Science and Technology Support Program(2015NZ0033)

Alkyl aluminum compounds are widely applied in organic reactions because of their high reactivities, low toxicities, and ease of preparation. The cross-coupling reaction of an organoalane compounds with organic electrophiles using a transition-metal catalyst or catalyst-free provides a simple method to synthesize a large variety of compounds and shows a higher functional group tolerance than organolithium and magnesium, which allows for additions to aldehydes in the presence of nitro, ester, hydroxyl, amino, nitrile and lactone moieties. Therefore, many organoalane reagents have found the most applications in cross-coupling reactions in recent years. In this paper, the recent research results about the alkylaluminum reagents applied in cross-coupling reactions are reviewed, involving various reaction systems.

Key words: alkylaluminum reagents, electrophilic reagents, cross-coupling reaction, carbon-carbon bond formation, carbon- heteroatom bond formation, transition-metal catalyst, catalyst-free