Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 412-418.DOI: 10.6023/cjoc201807051 Previous Articles     Next Articles

ARTICLE

灯盏花乙素半合成柳穿鱼叶苷研究

颜世强, 谢明现, 王玉杰, 李英霞   

  1. 复旦大学药学院 上海 201203
  • 收稿日期:2018-07-27 修回日期:2018-09-14 出版日期:2019-02-25 发布日期:2018-10-12
  • 通讯作者: 李英霞 E-mail:liyx417@fudan.edu.cn
  • 基金资助:

    国家自然科学基金(No.81773576)资助项目.

Research on the Semi-synthesis of Pectolinarin from Scutellarin

Yan Shiqiang, Xie Mingxian, Wang Yujie, Li Yingxia   

  1. School of Pharmacy, Fudan University, Shanghai 201203
  • Received:2018-07-27 Revised:2018-09-14 Online:2019-02-25 Published:2018-10-12
  • Contact: 10.6023/cjoc201807051 E-mail:liyx417@fudan.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81773576).

As the representative flavonoid and flavonoid glycoside of Chinese medicine Cirsium japonicum, pectolinarigenin and pectolinarin have important bioactivities. In this paper, the efficient semi-synthesis of pectolinarigenin had been achieved starting from commercially available scutellarin via a linear reaction sequence of 3 steps with the overall yield of 69.5%, wherein carboxyl esterification, selective hydroxy protecting, and glycosidic bond hydrolyzation were used. Afterwards, the chemical synthesis of pectolinarin had been accomplished by the glycosylation of pectolinarigenin and benzobromorutinose.

Key words: scutellarin, pectolinarigenin, pectolinarin, flavonoids, semi-synthesis