A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells

doi:10.6023/cjoc201804043

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 406-411.DOI: 10.6023/cjoc201804043 Previous Articles Next Articles

Special Issue: 荧光探针-生物传感合辑；有机超分子化学合辑

ARTICLE

基于新型萘环稠合硼氟二吡咯化合物(BODIPY)的氟离子荧光探针及其细胞成像研究

周建平^a, 吴保庚^a, 周志宽^a, 田蒋为^b, 袁爱华^a

a 江苏科技大学环境与化学工程学院镇江 212003;
b 中国药科大学中药学院南京 211198

收稿日期:2018-04-25 修回日期:2018-07-17 发布日期:2018-09-10
通讯作者: 周志宽, 田蒋为, 袁爱华 E-mail:zkzhou@just.edu.cn;jwtian@cpu.edu.cn;aihua.yuan@just.edu.cn
基金资助:
国家自然科学基金（Nos.21501073，21775166，51672114）及中国博士后基金（No.2017M621662）资助项目.

A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells

Zhou Jianping^a, Wu Baogeng^a, Zhou Zhikuan^a, Tian Jiangwei^b, Yuan Aihua^a

a School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003;
b Department of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198

Received:2018-04-25 Revised:2018-07-17 Published:2018-09-10
Contact: 10.6023/cjoc201804043 E-mail:zkzhou@just.edu.cn;jwtian@cpu.edu.cn;aihua.yuan@just.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21501073, 21775166, 51672114) and the China Postdoctoral Science Foundation (No. 2017M621662).

1. A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells.PDF(772KB)

Abstract

A colorimetric and fluorescent turn-off chemosensor for fluoride based on novel naphthalene-fused boron dipyrromethene (BODIPY) 5 was designed and synthesized. In various anions, only upon addition of fluoride, the UV-Vis absorption peak of probe 5 red-shifted 100 nm, reaching the near infrared (NIR) region. Thus, it can be used as naked-eye detector for fluoride ion. In the fluorescence test, upon addition of fluoride, the fluorescence of probe 5 quenched significantly. Confocal fluorescence microscopy experiments demonstrate that 5 can be used for monitoring fluoride in living cells.

Key words: boron dipyrromethene (BODIPY), near infrared (NIR), fluoride, fluorescent sensor

Cite this article

Zhou Jianping, Wu Baogeng, Zhou Zhikuan, Tian Jiangwei, Yuan Aihua. A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells[J]. Chin. J. Org. Chem., 2019, 39(2): 406-411.

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基于新型萘环稠合硼氟二吡咯化合物(BODIPY)的氟离子荧光探针及其细胞成像研究

A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells

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