First Total Synthesis of (±)-2,3,2",3"-Tetrahydroochnaflavone

doi:10.6023/cjoc201503029

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (10): 2114-2118.DOI: 10.6023/cjoc201503029 Previous Articles Next Articles

Articles

(±)-2,3,2",3"-Tetrahydroochnaflavone合成研究

张应鹏, 林森森, 石爱红, 杨云裳, 谭伟

兰州理工大学石油化工学院兰州 730050

收稿日期:2015-03-31 修回日期:2015-05-06 发布日期:2015-06-16
通讯作者: 张应鹏 E-mail:yingpengzhang@126.com
基金资助:
甘肃省自然科学基金(No. 2014GS03265)资助项目.

First Total Synthesis of (±)-2,3,2",3"-Tetrahydroochnaflavone

Zhang Yingpeng, Lin Sensen, Shi Aihong, Yang Yunshang, Tan Wei

School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050

Received:2015-03-31 Revised:2015-05-06 Published:2015-06-16
Supported by:
Project supported by the the Gansu Province Natural Science Fund Project (No: 2014GS03265).

1. First Total Synthesis of (±)-2,3,2",3"-Tetrahydroochnaflavone.PDF(1210KB)

Abstract

The first total synthesis of (±)-2,3,2",3"-tetrahydroochnaflavone has been achieved, which was isolated from the leaf of quintinia. The target molecular is consisting of naringenin and eriodictyol moieties, which was synthesized using 2,4,6-trihydroxyacetophenone and 4-hydroxybenzaldehyde as starting materials. The key steps in the synthesis of 2,3,2",3"-tetrahydroochnaflavone were the formation of a diaryl ether and cyclization of an ether-linked bichalcone to assemble the dihydroflavone, and the key synthetic intermediates are detailed.

Key words: (±, )-2,3,2",3"-tetrahydroochnaflavone, bioflavonoids, Ullmann reaction, total synthesis

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Zhang Yingpeng, Lin Sensen, Shi Aihong, Yang Yunshang, Tan Wei. First Total Synthesis of (±)-2,3,2",3"-Tetrahydroochnaflavone[J]. Chin. J. Org. Chem., 2015, 35(10): 2114-2118.

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(±)-2,3,2",3"-Tetrahydroochnaflavone合成研究

First Total Synthesis of (±)-2,3,2",3"-Tetrahydroochnaflavone

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