Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 1109-1115.DOI: 10.6023/cjoc201809020 Previous Articles     Next Articles



李春a,b, 王梦娜a, 陆逊花a, 杨元勇a, 张林a,b   

  1. a 贵州医科大学药学院 贵阳 550025;
    b 贵州医科大学天药用植物功效与利用国家重点实验室 贵阳 550014
  • 收稿日期:2018-09-15 修回日期:2018-11-30 出版日期:2019-04-25 发布日期:2018-12-07
  • 通讯作者: 张林
  • 基金资助:


Pd-Catalyzed N-Formylation of Amines with N,N-Dimethylformamide

Li Chuna,b, Wang Mengnaa, Lu Xunhuaa, Yang Yuanyonga, Zhang Lina,b   

  1. a School of Pharmacy, Guizhou Medical University, Guiyang 550004;
    b State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014
  • Received:2018-09-15 Revised:2018-11-30 Online:2019-04-25 Published:2018-12-07
  • Contact: 10.6023/cjoc201809020
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21562010,21601039).

A highly efficient protocol for the transamidation of N,N-dimethylformamide (DMF) and amines has been developed, utilizing a catalytic amount Pd(OAc)2. This methodology has a broad substrate scope for aliphatic, aromatic, and heterocyclic amines. And this process is simple and easily performed without solvent and co-catalyst.

Key words: Pd(OAc)2, N,N-dimethylformamide (DMF), amines, N-formylation