Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 727-733.DOI: 10.6023/cjoc201810003 Previous Articles     Next Articles

Articles

苯硫酚还原α,α,α-三溴甲基酮类化合物的研究

杨莹, 哈斯木江·巴拉提, 阿布都热西提·阿布力克木   

  1. 新疆师范大学化学系 乌鲁木齐 830054
  • 收稿日期:2018-10-05 修回日期:2018-11-07 出版日期:2019-03-25 发布日期:2018-11-26
  • 通讯作者: 阿布都热西提·阿布力克木 E-mail:aarexit@xjnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21662035)资助项目.

Research on Reduction of α,α,α-Tribromomethyl Ketones via Thiophenol

Yang Ying, Balati Hasimujiang, Abulikemu Abudu Rexit   

  1. Department of Chemistry, Xinjiang Normal University, Urumqi 830054
  • Received:2018-10-05 Revised:2018-11-07 Online:2019-03-25 Published:2018-11-26
  • Contact: 10.6023/cjoc201810003 E-mail:aarexit@xjnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21662035).

α,α-Dibromomethyl ketones were synthesized with high yields through a thiophenol-promoted reduction of α,α,α-tribromomethyl ketones under mild conditions within one hour. A further mechanistic study showed that the reaction proceeded via a radical process. This is an example that uses thiophenol as the radical stimulator in the reduction of multi-halogenated compounds.

Key words: thiophenol, α,α-dibromomethyl ketones, green synthesis, reduction