Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (2): 756-762.DOI: 10.6023/cjoc202206023 Previous Articles     Next Articles

α-酮酸与硫酚的电化学脱羧偶联: 一种合成硫代酸酯的新方法

黄嘉为, 李潇漫, 徐亮, 韦玉*()   

  1. 石河子大学化学化工学院 新疆兵团化工绿色过程重点实验室 新疆石河子 832003
  • 收稿日期:2022-09-06 修回日期:2022-09-21 发布日期:2022-10-31
  • 基金资助:

Electrochemical Decarboxylation Coupling of α-Keto Acids with Thiophenols: A New Avenue for the Synthesis of Thioesters

Jiawei Huang, Xiaoman Li, Liang Xu, Yu Wei()   

  1. Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, Xinjiang 832003
  • Received:2022-09-06 Revised:2022-09-21 Published:2022-10-31
  • Contact: *E-mail:
  • Supported by:
    National Natural Science Foundation of China(22061036)

Thioester compounds have been widely applied in the synthesis of bioactive chemicals, natural products and organic materials due to their versatile reactivities. In recent years, the decarboxylation coupling reactions between α-keto acids and thiols/thiophenols have been utilized to access thioesters. Herein, an electrochemical decarboxylation coupling method has been established, which uses α-keto acids and thiophenols as the starting materials and affords thioesters in moderate to good yields. This protocol features simple manipulation and avoids usually needed metal-based catalysts, bases or external oxidants, thus providing a new, mild, and green pathway to synthesize thioester compounds.

Key words: electrochemical synthesis, α-keto acid, thiophenol, thioester