Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (1): 122-128.DOI: 10.6023/cjoc201810026 Previous Articles     Next Articles

Special Issue: 庆祝陈庆云院士九十华诞 有机氟化学合辑



杨文铖, 亓晓旭, 陈品红, 刘国生   

  1. 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 分子合成科学卓越创新中心 上海 200032
  • 收稿日期:2018-10-20 修回日期:2018-12-03 发布日期:2018-12-05
  • 通讯作者: 陈品红, 刘国生;
  • 基金资助:


Palladium-Catalyzed Intramolecular Fluoroarylation of Alkenes

Yang Wencheng, Qi Xiaoxu, Chen Pinhong, Liu Guosheng   

  1. State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2018-10-20 Revised:2018-12-03 Published:2018-12-05
  • Contact: 10.6023/cjoc201810026;
  • Supported by:

    Project supported by he National Key R&D Program of China (973 Program, No. 2015CB856600), the National Natural Science Foundation of China (Nos. 21532009, 21672236, 21761142010, 21790330) and the Science Technology Commission of the Shanghai Municipality (Nos. 17QA1405200, 17JC1401200), and the Chinese Academy Sciences (Nos. XDB20000000, QYZDJSSW-SLH055) and the Youth Innovation Promotion Association (No.2018292).

A novel palladium-catalyzed intramolecular fluoroarylation of alkenes has been developed, in which ArIF2 was employed as fluorine source as well as I(Ⅲ) reagent to activate olefin, to deliver the fluoroarylation products from 4-aryl- 1-olefins in moderate to good yields. The current transformation presents a convenient method to provide fluorotetralins and fluorochromanes under mild conditions from alkenes tethered arenes.

Key words: palladium-catalyzed, alkenes, fluoroarylation, tetralin