Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (9): 2428-2442.DOI: 10.6023/cjoc201901031 Previous Articles     Next Articles

REVIEW

N-苄基脱除研究进展

周光伟, 张莉珠, 薛亚涵, 李加荣   

  1. 北京理工大学化学与化工学院 北京 100081
  • 收稿日期:2019-01-21 修回日期:2019-03-13 出版日期:2019-09-25 发布日期:2019-04-16
  • 通讯作者: 李加荣 E-mail:jrli@bit.edu.cn
  • 基金资助:

    086专项基金资助项目.

Progress of N-Benzyl Removal

Zhou Guangwei, Zhang Lizhu, Xue Yahan, Li Jiarong   

  1. School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081
  • Received:2019-01-21 Revised:2019-03-13 Online:2019-09-25 Published:2019-04-16
  • Contact: 10.6023/cjoc201901031 E-mail:jrli@bit.edu.cn
  • Supported by:

    Project supported by the 086 Special Fund.

N-Benzyl is a common protecting group for organic amines, owing to its convenient and efficient removal. It plays an important role in organic synthesis, especially in the research of drugs and natural products. In recent years, a large number of researchers have conducted extensive studies on N-benzyl deprotection, but the related work is scattered and lacks systematic review. Therefore, the progress of N-benzyl removal is systematically and comprehensively summarized from the aspects of reductive, oxidative and acid-base debenzylation.

Key words: organic amine, N-benzyl protection, reductive debenzylation, oxidative debenzylation, acid-base debenzylation