Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3583-3587.DOI: 10.6023/cjoc201904066 Previous Articles     Next Articles


李竣a, 徐晓诗a, 滕海达b, 陈玉b, 梅之南a, 杨光忠a   

  1. a 中南民族大学药学院 武汉 430074;
    b 中南民族大学化学与材料科学学院 武汉 430074
  • 收稿日期:2019-04-26 修回日期:2019-06-17 发布日期:2019-07-17
  • 通讯作者: 梅之南, 杨光忠;
  • 基金资助:

Chemical Constituents from Hypericum Erectum Thunb

Li Juna, Xu Xiaoshia, Teng Haidab, Chen Yub, Mei Zhinana, Yang Guangzhonga   

  1. a School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074;
    b College of Chemistry and Materials Sciences, South-Central University for Nationalities, Wuhan 430074
  • Received:2019-04-26 Revised:2019-06-17 Published:2019-07-17
  • Supported by:
    Project supported by the National Major New Drugs Innovation and Development (No. 2017ZX09301060) and the Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities (No. CZP18004).

The chemical constituents of Hypericum erectum Thunb were isolated and purified by solvent extraction method, the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography. Their structures were elucidated by their physicochemical property and extensive analysis of spectroscopic data. Three new compounds which belong to α-pyranone, flavonoid and aliphatic alcohol respectively, together with 15 known compounds, were isolated from the chloroform extract of H. erectum. Inflammatory cell model was constructed by lipopolysaccharide (LPS)-stimulated RAW264.7 cell line. NO production inhibitory effects of all tested compounds were measured by Griess method. Hyperiflavone (2), isocudraniaxan-thone B (5) and 2-deprenylrheediaxanthone B (6) exhibited moderate NO production inhibitory activities with the IC50 values of 16.24, 9.86 and 12.90 μmol·L-1, respectively.

Key words: Hypericum Linn, Hypericum erectum Thunb, xanthone, anti-inflammatory activity