Synthesis and Herbicidal Activity of Chiral Aryloxyphenoxypropionic Amides Compounds

doi:10.6023/cjoc201905028

Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3588-3593.DOI: 10.6023/cjoc201905028 Previous Articles Next Articles

手性芳氧苯氧丙酰胺类化合物的合成及除草活性研究

杨森^a, 丁成荣^a, 刘幸海^a, 翁建全^a, 袁静^b, 谭成侠^a

a 浙江工业大学化学工程学院杭州 310014;
b 浙江农林大学林业与生物技术学院杭州 311300

收稿日期:2019-05-13 修回日期:2019-06-03 发布日期:2019-06-19
通讯作者: 袁静, 谭成侠 E-mail:tanchengxia@zjut.edu.cn;1015251265@qq.com
基金资助:
国家重点研发计划（No.2017YFD0200507）资助项目.

Synthesis and Herbicidal Activity of Chiral Aryloxyphenoxypropionic Amides Compounds

Yang Sen^a, Ding Chengrong^a, Liu Xinghai^a, Weng Jianquan^a, Yuan Jing^b, Tan Chengxia^a

a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;
b College of Forestry and Biotechnology, Zhejiang Agriculture and Forestry University, Hangzhou 311300

Received:2019-05-13 Revised:2019-06-03 Published:2019-06-19
Supported by:
Project supported by the National Key R & D Program (No. 2017YFD0200507).

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Abstract

In order to find pesticidal lead compounds with high herbicidal activity, a series of novel chiral aryloxyphenoxypropionic amides were designed and synthesized using the principle of active substructure combination and the technology of biological enzyme splitting. The structures of the target compounds were confirmed by ¹H NMR and HRMS. The preliminary bioassay data showed that all target compounds displayed excellent herbicidal activity and selectivity against monocotyledonous weeds. At the dosage of 150 g/ha, the target compounds showed herbicidal activity against Backmannia syzigachne, Polypogon fugax and Poa acroleuca with more than 75%. And the control effects of three compounds against Polypogon fugax Nees were 100%.

Key words: aryloxyphenoxypropionic acids, herbicide, chirality, herbicidal activity, synthesize, enzyme splitting

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Yang Sen, Ding Chengrong, Liu Xinghai, Weng Jianquan, Yuan Jing, Tan Chengxia. Synthesis and Herbicidal Activity of Chiral Aryloxyphenoxypropionic Amides Compounds[J]. Chinese Journal of Organic Chemistry, 2019, 39(12): 3588-3593.

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手性芳氧苯氧丙酰胺类化合物的合成及除草活性研究

Synthesis and Herbicidal Activity of Chiral Aryloxyphenoxypropionic Amides Compounds

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