Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (3): 551-562.DOI: 10.6023/cjoc201911007 Previous Articles     Next Articles


谢涛a, 何海兵b, 高栓虎a,b   

  1. a 华东师范大学化学与分子工程学院 上海绿色化学与化工工程绿色化重点实验室 上海 200062;
    b 华东师范大学 上海分子治疗与新药创制工程技术研究中心 上海 200062
  • 收稿日期:2019-11-06 修回日期:2019-11-26 发布日期:2020-04-02
  • 通讯作者: 何海兵, 高栓虎;
  • 基金资助:

Synthetic Progress of Polycyclic Xanthone

Xie Taoa, He Haibingb, Gao Shuanhua,b   

  1. a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062;
    b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062
  • Received:2019-11-06 Revised:2019-11-26 Published:2020-04-02
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21971068, 21772044), the Program of Shanghai Academic/Technology Research Leader (No. 18XD1401500), the Program of Shanghai Science and Technology Committee (No. 18JC1411303), the National Young Top-Notch Talent Support Program and the Fundamental Research Funds for the Central Universities.

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated angular hexacyclic frameworks. In the last decade, there has been a noticeable increase in reports on both synthetic and pharmacological investigations of this class of natural molecules due to their unique chemical structures and biological activities. Most members of this class of molecules show strong activities towards Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, potent antifungal activity and antitumour activity. The synthetic studies of some members of this class of natural products is summarized.

Key words: polycyclic xanthone, natural product, total synthesis