Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3363-3374.DOI: 10.6023/cjoc201906026 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019


孙义明a, 丁奇峰a, 于杨c, 何益得c, 黄菲a,b   

  1. a 南京工业大学药学院 南京 211816;
    b 南京师范大学食品与制药工程学院 南京 210023;
    c 南京工业大学环境科学与工程学院 南京 211816
  • 收稿日期:2019-06-20 修回日期:2019-07-24 发布日期:2019-08-07
  • 通讯作者: 何益得, 黄菲;
  • 基金资助:

Progress in Co-Catalyzed C-H Amination

Sun Yiminga, Ding Qifenga, Yu Yangc, He Yidec, Huang Feia,b   

  1. a College of Pharmacy, Nanjing Tech University, Nanjing 211816;
    b College of Food and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023;
    c School of Environmental and Engineering, Nanjing Tech University, Nanjing 211816
  • Received:2019-06-20 Revised:2019-07-24 Published:2019-08-07
  • Supported by:
    Project supported by the Postdoctoral Science Foundation of China (No. 2019M651809), the Jiangsu Synergetic Innovation Center for Advanced Bio-manufacture (Nos. XTE1850, XTC1810), the Postdoctoral Science Foundation of Anhui Province (No. 2018B252) and the Natural Science Foundation of Jiangsu Province (No. BK20160989).

Amino compounds have a wide range of applications in the fields of organic chemistry, medicinal chemistry and functional materials. The efficient construction of C-N bonds has important research significance. Conventional amination reactions to construct C-N bonds require pre-functionalization of the substrate and inevitably produce quantitative halogenate by-products. The C-H amination reaction is directly based on hydrocarbons. The reaction has the advantages of "step" and "atomic" economy, in line with the green chemistry concept. Transition metal cobalt has the advantage of low toxicity and low cost. As a catalyst for C-H amination reaction, it exhibits its unique catalytic properties and attracts the attention of chemists. The research progress of cobalt-catalyzed C-H amination in recent years is summarized. At the same time, the challenges and development prospects of the research field are summarized and forecasted.

Key words: cobalt catalysis, C-H amination, amino compound