Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (4): 1559-1565.DOI: 10.6023/cjoc202209036 Previous Articles     Next Articles



高师泉a, 刘闯军b, 杨俊锋a,*(), 张俊良a,*()   

  1. a 复旦大学化学系 上海 200438
    b 黄淮学院化学与制药工程学院 河南驻马店 463000
  • 收稿日期:2022-09-29 修回日期:2022-10-31 发布日期:2022-11-15
  • 通讯作者: 杨俊锋, 张俊良
  • 基金资助:
    国家重点研发计划(2021YFF0701600); 国家自然科学基金(22031004); 国家自然科学基金(21921003); 国家自然科学基金(21901043); 国家自然科学基金(22271053); 上海市科学技术委员会(21ZR1445900); 上海市教育委员会项目(20212308); 河南省科技研发计划(192102210025)

Cobalt-Catalyzed Electrochemical Reductive Coupling of Alkynes and Alkenes

Shiquan Gaoa, Chuangjun Liub, Junfeng Yanga(), Junliang Zhanga()   

  1. a Department of Chemistry, Fudan University, Shanghai 200438
    b College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, Henan 463000
  • Received:2022-09-29 Revised:2022-10-31 Published:2022-11-15
  • Contact: Junfeng Yang, Junliang Zhang
  • Supported by:
    National Key Research and Development Program of China(2021YFF0701600); National Natural Science Foundation of China(22031004); National Natural Science Foundation of China(21921003); National Natural Science Foundation of China(21901043); National Natural Science Foundation of China(22271053); Science and Technology Commission of Shanghai Municipality(21ZR1445900); Shanghai Municipal Education Commission(20212308); Henan Provincial Science and Technology Research and Development Project(192102210025)

Transition-metal-catalyzed coupling reactions have now been extensively studied. However, the traditional reaction generally requires the addition of excessive amount of oxidant or reductive reagent. The new reaction mode of electro-organic synthesis avoids the usage of stoichiometric amount of redox reagent, which is more in line with the concept of green chemistry and atom economy. Recently cobalt catalysis has been discovered to be a cheap and low toxic alternative to noble transition-metal catalysts. In this paper, the reductive coupling reaction between alkynes and alkenes has been developed via electrochemistry by cobalt catalysis. The product could be delivered up to 90% yield with excellent regioselectivity.

Key words: electro-organic synthesis, cobalt catalysis, reductive coupling, alkyne, alkene