Synthesis of 3-Alkylthiol Pyrazoles via Regioselective Annulation Reactions of Sulfonyl Hydrazines and Ketene Dithioacetals

doi:10.6023/cjoc202005026

Abstract

By using sulfonyl hydrazines and ketene dithioacetals as starting materials, the regioselective annulation providing 3-alkylthiolated pyrazoles has been realized in the low cost and easily available NaHSO₄ catalytst. The reactions were realized in 1,4-dioxane medium and 80 ℃ heating, whereby a seris of 3-alkylthiol pyrazoles possessing N-sulfonyl structure have been efficiently synthesized.

Key words: ketene dithioacetal, sulfonyl hydrazine, annulation, regioselectivity, 3-alkylthiopyrazole

Cite this article

Li Yi, Wan Jieping. Synthesis of 3-Alkylthiol Pyrazoles via Regioselective Annulation Reactions of Sulfonyl Hydrazines and Ketene Dithioacetals[J]. Chinese Journal of Organic Chemistry, 2020, 40(11): 3889-3894.

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