Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2778-2787.DOI: 10.6023/cjoc202005051 Previous Articles     Next Articles


余接强a, 贾俊b, 王兴旺a   

  1. a 苏州大学材料与化学化工学部 江苏苏州 215123;
    b 苏州大学分析测试中心 江苏苏州 215123
  • 收稿日期:2020-05-19 修回日期:2020-06-22 发布日期:2020-07-09
  • 通讯作者: 贾俊, 王兴旺;
  • 基金资助:

Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds

Yu Jieqianga, Jia Junb, Wang Xingwanga   

  1. a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123;
    b Analysis and Testing Center, Soochow University, Suzhou, Jiangsu 215123
  • Received:2020-05-19 Revised:2020-06-22 Published:2020-07-09
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21971176).

Tryptophol derivatives are very important compounds with wide spectrum of pharmaceutical and physiological activity. Herein, the esterification reaction of trypthol and its derivatives with β,γ-unsaturated α-keto acids was reported by the use of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 1-hydroxybenzotriazole (HOBt) as conden-sation reagents. A series of β,γ-unsaturated α-keto trypanol ester derivatives were prepared in moderate to high yields. This method has advantages of riched functional group tolerance, readily available starting materials and easy operation.

Key words: condensation reagent, tryptophol, esterification, β,γ-unsaturated α-keto acid, β,γ-unsaturated α-keto trypanol ester